FIND OUT WHY THESE PRETTY FACES SPEND TIME IN BED FOR A LIFETIME

In Nepal there are 4 sisters all stricken by osteogenesis imperfecta or brittle bone disorder. they're unable to stay independent lives
Osteogenesis Imperfecta (OI) is a genetic bone sickness characterised through fragile bones that break without difficulty. it's also referred to as “brittle bone disease.” A person is born with this disorder and is affected for the duration of his or her existence time.

what's Osteogenesis Imperfecta (OI)?
Osteogenesis imperfecta (OI) or Brittle Bone sickness is a complicated, variable and rare sickness. Its primary function is a fragile skeleton, however many different frame systems are also affected. OI is resulting from a mutation (exchange) in a gene that impacts bone formation, bone energy and the structure of different tissues. it's far a lifestyles-long ailment. OI happens equally amongst ladies and men and in all racial companies. it's miles envisioned that approximately 25,000 to 50,000 human beings in the U.S. have OI. With correct medical control and supportive care, the majority of humans who've OI will lead healthy, productive lives and can anticipate a mean life span.
human beings with OI revel in frequent broken bones from infancy via puberty. The frequency typically decreases within the young person years but may additionally boom once more later in life. respiration troubles together with asthma are frequently seen. different clinical traits and troubles consist of:
Bone deformity, and bone pain.
quick stature.
backbone curves.
Low Bone Density.

loose joints, ligament laxity and muscle weakness are not unusual.
exceptional features of the cranium including late last fontanels, and head circumference extra than average.
listening to loss can also begin inside the early 20s and with the aid of middle age is present in more than 50% of human beings with OI.
Brittle tooth (called dentinogenesis imperfecta or DI) are seen in 50% of humans who've OI
breathing issues including asthma; can be aggravated by using chest wall deformity and/or spine deformity.
imaginative and prescient troubles which includes myopia and hazard for retinal detachment
pores and skin hyperlaxity; easy bruising.
Cardiac troubles.
Fatigue.
Basilar Invagination a severe neurological problem is visible in some people with the greater extreme types of OI.
pores and skin, blood vessels and inner organs may be fragile.